Reduced matrix rigidity promotes neonatal cardiomyocyte dedifferentiation, proliferation and clonal expansion

Cardiomyocyte (CM) maturation in mammals is accompanied by a sharp decline in their proliferative and regenerative potential shortly after birth.In this study, we explored the role of the mechanical properties of the underlying matrix in the regulation of CM maturation.We show that rat and mouse neonatal CMs cultured on rigid surfaces exhibited inc

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Assessing the Solubility of Baricitinib and Drug Uptake in Different Tissues Using Absorption and Fluorescence Spectroscopies

The low water solubility of baricitinib (BCT) limits the development of new formulations for the topical delivery of the drug.The aims of this study were to assess the solubility of BCT in different DUO ABSOLUT ARNICA solvents, including Transcutol, a biocompatible permeation enhancer that is miscible in water, to evaluate the drug uptake in human

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Key factors influencing the sale of bulls in livestock auctions

This research determines which factors most influence the purchase price of bulls in livestock auctions in the State of Outdoor Accessory Rio Grande do Sul, Southern Brazil.Hence, 760 beef bulls sold in eleven different auctions between August and November 2013 were analysed.The data consists of: breed, muscularity (MUSC), frame (FRAME), body condi

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